SUCLG2 - succinate-CoA ligase GDP-forming subunit beta Gene

Also Known as G-SCS; GBETA; GTPSCS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8801

About SUCLG2

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,360,460-67,654,612 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

SUCLG2 Products (2)

mRNA Protein Name
NM_001177599.2 NP_001171070.1 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor
NM_003848.4 NP_003839.2 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
24606901 GOA
Cellular Component GO Annotation Evidence Références Source
part of succinate-CoA ligase complex (GDP-forming) IPI
IPI: Inferred from physical interaction
32627745 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUCLG2 Protein Structure

ATP-grasp_2

ATP-grasp_2: ATP-grasp domain (39 - 245)

Ligase_CoA

Ligase_CoA: CoA-ligase (307 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

  • GTP-specific succinyl-CoA synthetase beta subunit

SUCLG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SUCLG2 Q96I99 SUCLG1 Homo sapiens P53597
Anti Tag CoIP
28514442
Intra
SUCLG2 Q96I99 SUCLG1 Homo sapiens P53597
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vitreous Abscess
Uvulitis

  • Acute Uvulitis
Ocular Albinism

  • Albinism, Ocular

  • Oa

  • Xloa

  • Albinism Ocular
Panophthalmitis
Lemierre'S Syndrome

  • Lemierre Syndrome

  • Lemierre Postanginal Sepsis

  • Necrobacillosis

  • Postanginal Sepsis Secondary To Orophyngeal Infection

  • Septic Phlebitis Of The Internal Jugular Vein

  • Fusobacterium Infections

  • Acute Sore Throat

  • Human Necrobacillosis

  • Postanginal Sepsis

  • Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Necrotizing Ulcerative Gingivitis

  • Acute Necrotizing Ulcerative Gingivitis

  • Anug

  • Vincent Angina

  • Vincent'S Disease

  • Acute Necrotising Ulcerative Gingivitis

  • Acute Necrotising Ulcerative Gingivostomatitis

  • Acute Necrotizing Ulcerative Gingivostomatitis

  • Acute Ulceromembranous Gingivitis

  • Angina - Vincents

  • Early Acute Necrotising Gingivitis

  • Trench Mouth

  • Vincent'S Angina

  • Vincent'S Angina - Pharyngitis

  • Vincent'S Infection, Any Site

  • Acute Membranous Gingivitis

  • Fusospirillary Gingivitis

  • Fusospirillosis

  • Phagedenic Gingivitis

  • Vincent'S Gingivitis

  • Vincent'S Infection

  • Vincent'S Stomatitis

  • Gingivitis, Necrotizing Ulcerative
Astigmatism
Purulent Endophthalmitis

  • Periocular Infection

  • Acute Endophthalmitis

  • Endophthalmia

  • Eye Infestation Nos

  • Intraocular Infection

  • Eye Infection Nos
Epiglottitis

  • Acute Epiglottitis

  • Acute Epiglottitis And Supraglottitis

  • Acute Epiglottiditis

  • Epiglottiditis

  • Epiglottitis Nos
Night Blindness, Congenital Stationary, Type 1h

  • Congenital Stationary Night Blindness 1h

  • CSNB1H

  • Congenital Stationary Night Blindness Type 1h

  • Night Blindness, Congenital Stationary, 1h
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14002 SUCLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20601 Suclg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27109 Suclg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SUCLG2 RGD RGD:1305008
Canis familiaris SUCLG2 VGNC VGNC:46967
Bos taurus SUCLG2 VGNC VGNC:35457
Macaca mulatta SUCLG2 VGNC VGNC:103873
Mus musculus SUCLG2 MGD MGI:1306824
Felis catus SUCLG2 VGNC VGNC:65826
Others SUCLG2 NCBI