GIC-20
GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma.
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- CAS No.: 2942242-60-4
- Formule: C38H37ClN4O5S
- Masse moléculaire:697.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| HT-1080 | IC50 |
1.6 μM
Compound: GIC-20
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Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 38593589] |
GIC-20 (1 μM, 48 h) inhibits proliferation and migration of HT1080 fibrosarcoma cells, exhibits cytotoxicity with IC50 of 1.6 μM[1].
GIC-20 (0.5-4 μM, 24 h) induces ferroptosis by inducing intracellular lipid peroxide and ROS accumulation, or by degradation of GPX4[1].
GIC-20 (0-1 μM, 24 h) inhibits cell viability of drug-resistant MIA-PaCa-2-AMG510R cells, enhances the sensitivity of MIA-PaCa-2-AMG510R cells to AMG510[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080
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Concentration:0-4 μM
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Incubation Time:24 h
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Result:Inhibited expression of GPX4 and Bcl-2, promoted expression of Bax.
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Cell Line:HT1080
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Concentration:0-4 μM
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Incubation Time:24 h
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Result:Induced apoptosis in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT1080 xenograft BALB/c mice[1]
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Dosage:20-40 mg/kg
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Administration:i.p., once a day for 19 days
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Result:Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs.
Chemical Information
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CAS No. 2942242-60-4
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Masse moléculaire 697.24
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Formule C38H37ClN4O5S
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SMILES
O=C1C=C(NCCCCCC(NC2=CC=C(N(C(C(NCCC3=CC=CC=C3)=O)C4=CC=CS4)C(CCl)=O)C=C2)=O)C(C5=CC=CC=C51)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GIC-20 Related Classifications
HY-162449 Related Classifications
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