Globo H
Globo H is a carbohydrate antigen belonging to the globo-series glycosphingolipids, and its non-reducing terminal tetrasaccharide fragment serves as the core epitope recognized by antibodies. Globo H is upregulated in a variety of human cancer tissues, and is also present in some normal fetal and adult epithelial tissues. Globo H can be used in cancer-related research.
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- CAS No.: 207384-96-1
- Formule: C38H65NO30
- Masse moléculaire:1015.91
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
In Vitro
Globo H, in the forms of Globo H‑BSA and Globo H‑ceramide, binds strongly to mAb VK‑9. This antigen achieves optimal binding to mAb VK‑9 via its 4 non-reducing terminal sugar sequences, while internal α‑GalNAc linkage modifications reduce binding affinity. Mixed hemagglutination assays confirm that this antigen is highly expressed on the surface of MCF‑7 human breast cancer cells and binds strongly to mAb VK‑9. Immunocytochemical detection shows only weak binding to SK‑OV‑4 human ovarian cancer cells and T47D human breast cancer cells, with no binding observed in the other tested cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 207384-96-1
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Masse moléculaire 1015.91
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Formule C38H65NO30
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SMILES
CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@H]2[C@H]([C@H](O[C@@H]([C@@H]2O)CO)O[C@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@H]([C@@H]([C@H]4O)O)O)CO)CO)O)CO)O)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O)O[C@H]6[C@H]([C@@H]([C@@H]([C@@H](O6)C)O)O)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Globo H Related Classifications
HY-188125 Related Classifications
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