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Cat. No.: HY-139226

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GMQ

(Synonyms: 2-Guanidine-4-methylquinazoline)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

GMQ is an acid-sensing ion channel modulator, competitive GABA_AR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α₁β₂, α₁β₂γ₂, α₄β₂γ₂ and α₅β₂γ₂ GABA_ARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.

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CAS No.: 716-11-0
Formule: C₁₀H₁₁N₅
Masse moléculaire:201.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

GMQ Chemical Structure

CAS No.: 716-11-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	66.41 μM Compound: GNF-Pf-3515	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
L6	CC₅₀	>64 μM Compound: 20	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19364854]

Chemical Information

CAS No. 716-11-0
Masse moléculaire 201.23
Formule C₁₀H₁₁N₅
SMILES

NC(NC1=NC(C)=C2C=CC=CC2=N1)=N
Synonyms

2-Guanidine-4-methylquinazoline
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Eur J Pharmacol

2-guanidine-4-methylquinazoline inhibits platelet activation and thrombosis by targeting the acid-sensing ion channel 3. [Abstract]

2026 May 30:1030:179005. PMID: 42219052

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xiao X, et al. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors. Neuropharmacology. 2013 Dec;75:126-37. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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Activité biologique
- Description
Chemical Information
Publications (1)
Pureté et documentation
Références

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GMQ

Publications Citing Use of MedChemExpress (MCE) GMQ