hAChE-IN-3
hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， MAO-B-IN-1 and BACE-1 inhibitor, with IC50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease.
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- CAS No.: 2983723-56-2
- Formule: C30H24ClN3O5
- Masse moléculaire:541.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MAO-B 5.15 μM (IC50) |
AChE 0.44 μM (IC50) |
BChE 0.08 μM (IC50) |
hAChE-IN-3 (compounds 5c) has IC50 values of 36.28 μM (24 h) for SH-SY5Y cell line and 154.10 μM (48 h) for HepG2 cell line[1].
hAChE-IN-3 has IC50 values of 2.58 μM of inhibition of Aβ Aggregation and 59% inhibition at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2983723-56-2
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Masse moléculaire 541.98
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Formule C30H24ClN3O5
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SMILES
O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=CC([N+]([O-])=O)=C4)C5=C(N)C6=C(N=C5O3)CCCC6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hAChE-IN-3 Related Classifications
HY-155085 Related Classifications
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