HexylHIBO hydrobromide
HexylHIBO hydrobromide is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO hydrobromide does not inhibits mGlu2 and mGlu4a. HexylHIBO hydrobromide decreases spontaneous excitatory postsynaptic currents (sEPSCs) in rat.
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- Formule: C12H21BrN2O4
- Masse moléculaire:337.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
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mGluR1a 140 μM (Kb) |
mGluR5a 110 μM (Kb) |
Chemical Information
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Masse moléculaire 337.21
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Formule C12H21BrN2O4
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SMILES
O=C1C(CCCCCC)=C(ON1)CC(C(O)=O)N.Br
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059. [Content Brief]
[2]. Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HexylHIBO hydrobromide Related Classifications
HY-175100 Related Classifications
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