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Cat. No.: HY-136686

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IDH-C227

IDH-C227 is a potent and selective IDH1^R132H inhibitor. IDH-C227 has anticancer effcts.

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CAS No.: 1355324-14-9
Formule: C₃₀H₃₁FN₄O₂
Masse moléculaire:498.59

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IDH-C227 Chemical Structure

CAS No.: 1355324-14-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IDH-C227 is a potent and selective IDH1^R132H inhibitor. IDH-C227 has anticancer effcts^[1].

Voir tous les produits spécifiques à Isoform Isocitrate Dehydrogenase (IDH) :

IDH1
IDH2

In Vitro

IDH-C227 shows anticancer effcts, with IC₅₀ values of <0.1 μM and 0.25 μM against HT1080 and U87MG cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1355324-14-9
Masse moléculaire 498.59
Formule C₃₀H₃₁FN₄O₂
SMILES

N#CC1=CC=C(NCC(N(C(C2=C(C)C=CC=C2)C(NC3CCCCC3)=O)C4=CC(F)=CC=C4)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hanumantha Rao Madala, et al. Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies. Cancers (Basel). 2018 Feb 11;10(2):49. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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IDH-C227

Voir tous les produits spécifiques à Isoform Isocitrate Dehydrogenase (IDH)