LasR-IN-2
LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3033530-61-6
- Formule: C21H16ClN3O2
- Masse moléculaire:377.82
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
LasR[1]
LasR-IN-2 (Compound 8a, 4.68-150 μg/mL, 24 h) inhibits P. aeruginosa growth[1].
LasR-IN-2 (18.5 μM, 24 h) inhibits biofilm formation, pyocyanin production, and rhamnolipids production[1].
LasR-IN-2 (24 h) inhibits human dermal fibroblasts (HDFa) growth with an IC50 value of 102 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. aeruginosa (ATCC27853)
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Concentration:4.68-150 μg/mL
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Incubation Time:24 h
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Result:Inhibited bacterial growth with a MIC value of 74.40 μM.
Chemical Information
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CAS No. 3033530-61-6
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Masse moléculaire 377.82
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Formule C21H16ClN3O2
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SMILES
O=C(NC1=CC=CC=C1)COC2=CC=C(C3=NC4=CC(Cl)=CC=C4N3)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Rehab H Abd El-Aleam, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LasR-IN-2 Related Classifications
HY-151164 Related Classifications
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