Explore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis.
Centres d’apprentissage
-
Mitochondrial Control of Cellular Senescence: Quality Control, Innate Immunity, and Metabolic–Epigenetic Regulation -
Beyond One Brake: How Tumours Dynamically Rewire the Immune Checkpoint Network Explore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification. -
Evolution of PCSK9 Inhibitors Modalities: From Monoclonal Antibodies to Oral Macrocyclic Peptides Review the biological basis of PCSK9, key therapeutic modalities, cardiovascular evidence, and future directions, including insights from the CORALreef clinical program. -
Engineering mRNA Therapeutics: Molecular Design, Targeted Delivery, and Translational Challenges Explore advances in mRNA molecular design and targeted delivery, emerging non-LNP platforms, and key translational challenges shaping broader applications beyond vaccines.
