M62812 free base
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 613262-61-6
- Formule: C13H11N3OS
- Masse moléculaire:257.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
7 μM
Compound: 23
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Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
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[PMID: 18828583] |
| PBMC | IC50 |
3 μM
Compound: 23
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Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation
Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation
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[PMID: 18828583] |
In Vitro
M62812 (0-10 μg/ml) suppresses LPS-induced upregulation of inflammatory cytokines, adhesion molecules and procoagulant activity in human vascular endothelial cells and peripheral mononuclear cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:D-galactosamine-sensitized endotoxin shock mouse model[1]
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Dosage:10-20 mg/kg
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Administration:Single intravenous administration
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Result:Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
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Animal Model:A cecal ligation and puncture mouse model[1]
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Dosage:20 mg/kg
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Administration:Intravenous administration; Everyday
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Result:Reduced mortality in a murine cecal ligation and puncture model.
Chemical Information
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CAS No. 613262-61-6
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Masse moléculaire 257.31
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Formule C13H11N3OS
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SMILES
NC1=NSC2=C1C=CC(OC3=CC=CC=C3N)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M62812 free base Related Classifications
HY-103639 Related Classifications
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