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Cat. No.: HY-B1482AS

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Mesoridazine-d₃

Mesoridazine-d₃ is the deuterium labeled Mesoridazine (HY-B1482A). Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells.Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders.

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CAS No.: 2514954-64-2
Formule: C₂₁H₂₃D₃N₂OS₂
Masse moléculaire:389.59

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (247 KB)

Mesoridazine-d₃ Chemical Structure

CAS No.: 2514954-64-2

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Activité biologique

Description

Mesoridazine-d₃ is the deuterium labeled Mesoridazine (HY-B1482A). Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells^[1].Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders^[1]^[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2514954-64-2
Unlabeled Cas 5588-33-0
Masse moléculaire 389.59
Formule C₂₁H₂₃D₃N₂OS₂
SMILES

O=S(C(C=C1N2CCC3N(C([2H])([2H])[2H])CCCC3)=CC=C1SC4=C2C=CC=C4)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.