N-Deacetylcolchicine
Based on 1 Customer Validation
N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.38%
- CAS No.: 3476-50-4
- Formule: C20H23NO5
- Masse moléculaire:357.40
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Protein-protein Interaction Inhibitor Library
HY-L109
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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High-Efficiency Gene Editing Compound Library
HY-L244
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Lactylation Compound Library
HY-L249
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Cell Cycle/DNA Damage Compound Library
HY-L004
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GPCR/G Protein Compound Library
HY-L006
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Cytoskeleton Compound Library
HY-L060
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Anti-Lung Cancer Compound Library
HY-L075
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.036 μM
Compound: 15
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Cytotoxicity against human A549 cells after 96 hrs using tetracolor one
Cytotoxicity against human A549 cells after 96 hrs using tetracolor one
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[PMID: 24900316] |
| H9 | EC50 |
0.2 μM
Compound: 2
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Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
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[PMID: 1919593] |
| H9 | IC50 |
0.2 μM
Compound: 2
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Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
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[PMID: 1919593] |
| HBL-100 | IC50 |
0.045 μM
Compound: 2
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Antiproliferative activity against human HBL100 after 72 hrs by MTT assay
Antiproliferative activity against human HBL100 after 72 hrs by MTT assay
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[PMID: 22739088] |
| HT-29 | IC50 |
0.025 μM
Compound: 15
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Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one
Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one
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[PMID: 24900316] |
| HUVEC | IC50 |
0.034 μM
Compound: 15
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Cytotoxicity against human HUVEC cells after 96 hrs using tetracolor one
Cytotoxicity against human HUVEC cells after 96 hrs using tetracolor one
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[PMID: 24900316] |
Chemical Information
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CAS No. 3476-50-4
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Appearance Solid
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Masse moléculaire 357.40
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Formule C20H23NO5
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Color Light yellow to yellow
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SMILES
COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(OC)C3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 10 mg/mL (27.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Muzaffar, A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33(2), 567-571 (1990). [Content Brief]
[2]. Lin, et al. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256(17), 9242-9245 (1981). [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7980 mL | 13.9899 mL | 27.9799 mL | 69.9496 mL |
| 5 mM | 0.5596 mL | 2.7980 mL | 5.5960 mL | 13.9899 mL | |
| 10 mM | 0.2798 mL | 1.3990 mL | 2.7980 mL | 6.9950 mL | |
| 15 mM | 0.1865 mL | 0.9327 mL | 1.8653 mL | 4.6633 mL | |
| 20 mM | 0.1399 mL | 0.6995 mL | 1.3990 mL | 3.4975 mL | |
| 25 mM | 0.1119 mL | 0.5596 mL | 1.1192 mL | 2.7980 mL |
N-Deacetylcolchicine Related Classifications
HY-121434 Related Classifications
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