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Pegpleranib

(Synonyms: Fovista)

Pegpleranib (Fovista) is a pegylated DNA aptamer that selectively binds to PDGF-BB and PDGF-AB homodimers and heterodimers, interrupting the interaction with their associated tyrosine kinase receptors.

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  • Pegpleranib Chemical Structure
    Pegpleranib Chemical Structure
CAS No.: 1618657-13-8
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  • Pegpleranib Chemical Structure
    Pegpleranib Chemical Structure Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5'-ester with DNA d(C-A-G-G-C-(2'-deoxy-2'-fluoro)rU-A-(2'-deoxy-2'-fluoro)rC-rGm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyphosphinicooxy)C-G-T-A-rGm-A-rGm-C-A-(2'-deoxy-2'-fluoro)rU-(2'-deoxy-2'-fluoro)rC-rAm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyphosphinicooxy)T-G-A-T-(2'-deoxy-2'-fluoro)rC-(2'-deoxy-2'-fluoro)rC-(2'-deoxy-2'-fluoro)rU-rGm-(3'→3')-T) 5'-[6-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]hexyl hydrogen phosphate] (2:1)
    1/16
  • Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5'-ester with DNA d(C-A-G-G-C-(2'-deoxy-2'-fluoro)rU-A-(2'-deoxy-2'-fluoro)rC-rGm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyphosphinicooxy)C-G-T-A-rGm-A-rGm-C-A-(2'-deoxy-2'-fluoro)rU-(2'-deoxy-2'-fluoro)rC-rAm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyphosphinicooxy)T-G-A-T-(2'-deoxy-2'-fluoro)rC-(2'-deoxy-2'-fluoro)rC-(2'-deoxy-2'-fluoro)rU-rGm-(3'→3')-T) 5'-[6-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]hexyl hydrogen phosphate] (2:1)