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Cat. No.: HY-120270

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PF-06679142

PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC₅₀ of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research.

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CAS No.: 1467059-66-0
Formule: C₂₀H₁₇F₂NO₃
Masse moléculaire:357.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PF-06679142 Chemical Structure

CAS No.: 1467059-66-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC₅₀ of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research^[1].

IC₅₀ & Target

AMPK α1β1γ1

22 nM (EC₅₀)

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Chemical Information

CAS No. 1467059-66-0
Masse moléculaire 357.35
Formule C₂₀H₁₇F₂NO₃
SMILES

OC(C1=CNC2=CC(F)=C(C3=CC=C([C@]4([H])CCCCO4)C=C3)C(F)=C21)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Edmonds DJ, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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PF-06679142

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform AMPK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PF-06679142 Related Classifications

HY-120270 Related Classifications