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Cat. No.: HY-153512

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PHD-1-IN-3

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion.

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CAS No.: 2009345-20-2
Formule: C₁₄H₁₁N₅
Masse moléculaire:249.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

PHD-1-IN-3 Chemical Structure

CAS No.: 2009345-20-2

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Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion^[1].

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase :

In Vitro

PHD-1-IN-3 (compound 53) acts as an MDR1 substrate in MDR1-MDCK cell monolayers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC_0-t	C_max	F
Mice^[1]	3 mg/kg	p.o.	/	40038 ng·h/mL	14.8 μM	39 %
Mice^[1]	0.5 mg/kg	i.v.	0.48 mL/min/kg	/	/	/

Chemical Information

CAS No. 2009345-20-2
Masse moléculaire 249.28
Formule C₁₄H₁₁N₅
SMILES

N#CC=1C=CC(C2=CC(N)=CC3=NC=NN32)=C(C1)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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PHD-1-IN-3

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PHD-1-IN-3 Related Classifications

HY-153512 Related Classifications