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Cat. No.: HY-183965

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PLK3-IN-1

PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC₅₀ of 5 nM. PLK3-IN-1 can be used for cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₇H₂₉FN₈O
Masse moléculaire:500.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

PLK3-IN-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC₅₀ of 5 nM. PLK3-IN-1 can be used for cancer research^[1].

Voir tous les produits spécifiques à Isoform Polo-like Kinase (PLK) :

In Vitro

PLK3-IN-1 (Compound 9) potently inhibits purified PLK3 with an IC₅₀ of 0.005 μM, and exhibits 1000-fold selectivity over PLK1 and 60-fold selectivity over PLK2 in a biochemical kinase inhibition assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 500.57
Formule C₂₇H₂₉FN₈O
SMILES

CN1CCC[C@H](C1)C2=CNC3=CC=C(C=C32)NC4=NC=C(C(N5CCN(C(C5)=O)C6=CC=CC=N6)=N4)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yap JL, et al. Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. ACS Med. Chem. Lett. 2026 May 12.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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PLK3-IN-1

Voir tous les produits spécifiques à Isoform Polo-like Kinase (PLK)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PLK3-IN-1 Related Classifications

HY-183965 Related Classifications