CK2
Casein kinase 2 is exceptional among CMGC kinases in being constitutively active and insensitive to second messengers. Two catalytic genes, CSNK2A1 (alpha) and CSNK2A2 (alpha'), assemble with the CSNK2B regulatory beta subunit into an alpha2beta2 holoenzyme that phosphorylates acidic consensus sequences of the form Ser/Thr-x-x-Asp/Glu. Its substrate list runs into the hundreds and spans NF-kappaB activation, Wnt signaling, circadian timing, DNA repair, suppression of apoptosis and ribosome biogenesis. CK2 is consistently overexpressed or hyperactive in tumors and supports cell survival, which has driven clinical development of ATP-competitive inhibitors including silmitasertib (CX-4945) and the halogenated benzimidazole TBB.
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CK2 Protéines Recombinantes (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
