IL-24
Interleukin-24 (IL-24), also known as melanoma differentiation-associated gene 7 (MDA-7), is a member of the IL-10 family that functions as a tumor suppressor cytokine. It is secreted by activated monocytes, T cells, melanocytes and keratinocytes, and signals through two receptor complexes-IL-20Rα/IL-20Rβ and IL-22Rα1/IL-20Rβ-activating STAT1 and STAT3. Unlike most cytokines, IL-24 selectively induces apoptosis and toxic autophagy in tumor cells by upregulating pro-apoptotic factors (BAX, BAK), suppressing anti-apoptotic proteins (BCL-2, BCL-XL) and generating reactive oxygen species, while sparing normal cells. It additionally inhibits tumor angiogenesis, sensitizes cancer cells to radiation and chemotherapy, and exhibits anti-angiogenic and wound-healing properties in skin. IL-24 loss during melanoma progression made it a pioneering cancer gene therapy (INGN 241) evaluated in clinical trials for multiple advanced malignancies.
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IL-24 Protéines Recombinantes (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
