(S)-BMS-378806
(S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA.
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- CAS No.: 357263-14-0
- Formule: C22H22N4O4
- Masse moléculaire:406.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 357263-14-0
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Masse moléculaire 406.43
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Formule C22H22N4O4
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SMILES
C[C@@H]1N(CCN(C1)C(C2=CC=CC=C2)=O)C(C(C3=CNC4=NC=CC(OC)=C43)=O)=O
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Synonyms
(S)-BMS-806
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-BMS-378806 Related Classifications
HY-119202 Related Classifications
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