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Cat. No.: HY-123524

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STAT3-IN-4

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells.

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CAS No.: 825611-06-1
Formule: C₂₀H₁₃NO₅S
Masse moléculaire:379.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STAT3-IN-4 Chemical Structure

CAS No.: 825611-06-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	63.77 μM Compound: B9	Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MCF7	IC₅₀	133.7 μM Compound: B9	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-231	IC₅₀	13.8 μM Compound: B9	Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-468	IC₅₀	5.1 μM Compound: B9	Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]

Chemical Information

CAS No. 825611-06-1
Masse moléculaire 379.39
Formule C₂₀H₁₃NO₅S
SMILES

O=S(C1=CC=C(C(C2=C3C=CC=C2)=O)C(C3=O)=C1)(NC4=CC=C(C=C4)O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huang M, et al. Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5172-5176. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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STAT3-IN-4

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

STAT3-IN-4 Related Classifications

HY-123524 Related Classifications