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Recent Posts
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Optogenetics: From Light-Gated Ion Channels to Causal NeuroscienceExplore optogenetics through its molecular mechanisms, experimental strategies, research applications, and translational advances.
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Mapping Cancer Vulnerabilities: The Expanding Landscape of Synthetic LethalityExplore emerging synthetic lethal vulnerabilities beyond BRCA–PARP and advances in their discovery and prediction through CRISPR screening, organoids, multi-omics, and AI.
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Metabolic Regulation of Ferroptosis: Iron, Lipids and PolyaminesReview the metabolic regulation of ferroptosis through iron homeostasis, lipid peroxidation and antioxidant defence, and the emerging polyamine–iron buffering axis.
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Conserved Antiviral Immunity Across Domains of Life: From Pathogen Sensing to Effector ResponsesExplore conserved antiviral mechanisms across mammals and bacteria, from virus recognition and immune signaling to metabolic defense and gasdermin-mediated cell death, and their implications for innate immune evolution.
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Mitochondrial Control of Cellular Senescence: Quality Control, Innate Immunity, and Metabolic–Epigenetic RegulationExplore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis.
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Beyond PD-1: How Immune Checkpoint Networks Shape Tumor ImmunityExplore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification.