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Cat. No.: HY-120356

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T-1101

Name: T-1101
Brand: MedChemExpress
SKU: HY-120356
Availability: PreOrder

(Synonyms: TAI-95)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.

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CAS No.: 1438638-83-5
Formule: C₂₄H₂₃N₅O₃S₂
Masse moléculaire:493.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

T-1101 Chemical Structure

CAS No.: 1438638-83-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

IC₅₀ & Target

NEK2

Voir tous les produits spécifiques à Isoform NEKs :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	GI₅₀	29.1 nM Compound: 9j	Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
HeLa	IC₅₀	21.1 nM Compound: 9j	Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
Huh-7	GI₅₀	34.98 nM Compound: 9j	Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
Huh-7	GI₅₀	59.9 nM Compound: 9j	Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
K562	IC₅₀	18 nM Compound: 9j	Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
MDA-MB-231	IC₅₀	14.8 nM Compound: 9j	Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
MDA-MB-468	IC₅₀	21.5 nM Compound: 9j	Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
U2OS	GI₅₀	83.2 nM Compound: 9j	Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
U-937	GI₅₀	12.4 nM Compound: 9j	Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]

Chemical Information

CAS No. 1438638-83-5
Masse moléculaire 493.60
Formule C₂₄H₂₃N₅O₃S₂
SMILES

O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
Synonyms

TAI-95
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Cancer Res Commun

Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden. [Abstract]

2024 Apr 9;4(4):1024-1040. PMID: 38592451

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huang LY, et al., Inhibition of Hec1 as a novel approach for treatment of primary liver cancer. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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T-1101

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Pureté et documentation
Références

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T-1101

Publications Citing Use of MedChemExpress (MCE) T-1101

Voir tous les produits spécifiques à Isoform NEKs

Activité biologique

Chemical Information

Publications (1)

Pureté et documentation

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T-1101 Related Classifications

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