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Teprotumumab

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Based on 1 publication(s) in Google Scholar

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.

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  • Pureté: 99.46%
  • CAS No.: 1036734-93-6
  • Masse moléculaire:145.671 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Teprotumumab
  • Experimental Validation Results for Teprotumumab
  • Experimental Validation Results for Teprotumumab
  • Experimental Validation Results for Teprotumumab
  • Teprotumumab Chemical Structure
    Teprotumumab Chemical Structure
CAS No.: 1036734-93-6
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Teprotumumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IGF-I R Protein, Human (HEK293, His, HY-P72606) can bind Teprotumumab. The EC50 for this effect is 1.568 ng/mL.

  • 1/16

    Loaded Teprotumumab on AHC2 biosensor, can bind IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78142) with an affinity constant of 4.315E-10 M as determined in BLI assay.

  • 1/16

    Teprotumumab purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jan 16;135(2):e178198. [Abstract]

    Customer Validation
     Real-time PCR of gene expression in MFS patient-specific iPSC-derived VSMCs with conditioned media treatment in the presence of Teprotumumab (200 μg/mL; 24 h) or IgG. n = 4.

  • Teprotumumab Chemical Structure
    1/16
  • Teprotumumab
  • Immobilized IGF-I R Protein, Human (HEK293, His, HY-P72606) can bind Teprotumumab. The EC50 for this effect is 1.568 ng/mL.
  • Loaded Teprotumumab on AHC2 biosensor, can bind IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78142) with an affinity constant of 4.315E-10 M as determined in BLI assay.