Tylogenin
Tylogenin is a Na+/K+ ATPase inhibitor with an IC50 of 93.3 μM against rabbit-derived targets. Tylogenin inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes. Tylogenin exhibits antiallergic activity. Tylogenin can be used in research related to allergic diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 135247-46-0
- Formule: C28H38O10
- Masse moléculaire:534.60
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Tylogenin (1-300 μM; 15-120 min) exhibits time-dependent inhibition of antigen-induced serotonin release from sensitized rabbit basophils in the BDSR assay, with an IC50 of 38.90 μM after 120 min of incubation, and the inhibition rate reaches 92% at a concentration of 300 μM following 120 min of incubation[1].
Tylogenin (1-300 μM; 4 h) inhibits antigen-induced Histamine (HY-B1204) release from leukocytes of atopic individuals in the LDHR assay, with an IC50 of 48.98 μM[1].
Tylogenin (5-2000 μM; 1 h) inhibits Na+/K+ ATPase activity in rabbit renal cortical basolateral membrane vesicles, with an IC50 of 93.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 135247-46-0
-
Masse moléculaire 534.60
-
Formule C28H38O10
-
SMILES
C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.
[2]. Gnabre JN, et al. Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. International journal of immunopharmacology. 1994 Aug;16(8):641-50. [Content Brief]
[3]. Gnabre JN, et al. Tylophora compounds as Na+/K(+)-ATPase inhibitors. Gen Pharmacol. 1993 Sep;24(5):1107-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tylogenin Related Classifications
HY-183389 Related Classifications
Powered by Bioz