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Cat. No.: HY-183389

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Tylogenin

Tylogenin is a Na⁺/K⁺ ATPase inhibitor with an IC₅₀ of 93.3 μM against rabbit-derived targets. Tylogenin inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes. Tylogenin exhibits antiallergic activity. Tylogenin can be used in research related to allergic diseases.

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CAS No.: 135247-46-0
Formule: C₂₈H₃₈O₁₀
Masse moléculaire:534.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Tylogenin Chemical Structure

CAS No.: 135247-46-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

Tylogenin (1-300 μM; 15-120 min) exhibits time-dependent inhibition of antigen-induced serotonin release from sensitized rabbit basophils in the BDSR assay, with an IC₅₀ of 38.90 μM after 120 min of incubation, and the inhibition rate reaches 92% at a concentration of 300 μM following 120 min of incubation^[1].
Tylogenin (1-300 μM; 4 h) inhibits antigen-induced Histamine (HY-B1204) release from leukocytes of atopic individuals in the LDHR assay, with an IC₅₀ of 48.98 μM^[1].
Tylogenin (5-2000 μM; 1 h) inhibits Na⁺/K⁺ ATPase activity in rabbit renal cortical basolateral membrane vesicles, with an IC₅₀ of 93.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 135247-46-0
Masse moléculaire 534.60
Formule C₂₈H₃₈O₁₀
SMILES

C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.

[2]. Gnabre JN, et al. Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. International journal of immunopharmacology. 1994 Aug;16(8):641-50. [Content Brief]

[3]. Gnabre JN, et al. Tylophora compounds as Na+/K(+)-ATPase inhibitors. Gen Pharmacol. 1993 Sep;24(5):1107-13. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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