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Zubotamig

(Synonyms: Gen1047)
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Based on 1 Customer Validation

Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer).

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  • Pureté: 96.46%
  • CAS No.: 2640279-10-1
  • Masse moléculaire:144.74 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Zubotamig
  • Experimental Validation Results for Zubotamig
  • Experimental Validation Results for Zubotamig
  • Experimental Validation Results for Zubotamig
  • Zubotamig Chemical Structure
    Zubotamig Chemical Structure
CAS No.: 2640279-10-1
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Zubotamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-kappa

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Zubotamig. The EC50 for this effect is 17.19 ng/mL.

  • 1/16

    Immobilized B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78073) can bind Zubotamig. The EC50 for this effect is 29.2 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling CD3E with Zubotamig (HY-P990953, red). Cells were stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Zubotamig Chemical Structure
    1/16
  • Zubotamig
  • Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Zubotamig. The EC50 for this effect is 17.19 ng/mL.
  • Immobilized B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78073) can bind Zubotamig. The EC50 for this effect is 29.2 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells labeling CD3E with Zubotamig (HY-P990953, red). Cells were stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-lambda-kappa