1000023-04-0
Chemical Structure
Voruciclib
- CAS. Nr.: 1000023-04-0
- Formula:C22H19ClF3NO5
- Molecular Weight:469.84
IUPAC Name: 2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
InChIKey: MRPGRAKIAJJGMM-OCCSQVGLSA-N
SMILES: O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13
Biological Activity: Voruciclib is an orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL)[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Voruciclib | 99.76% | Voruciclib is an orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL). | ||||||||||||||||||||
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Similarity Score 1.00
HY-12422Crel-(2S,3R)-Voruciclib -
Similarity Score 0.99
HY-12422AVoruciclib hydrochloride -
Similarity Score 0.99
HY-12422B(2S,3R)-Voruciclib hydrochloride -
Similarity Score 0.99
HY-12422Erel-(2S,3R)-Voruciclib hydrochloride -
Similarity Score 0.83
HY-16559Riviciclib hydrochloride -
Similarity Score 0.83
HY-16559ARiviciclib -
Similarity Score 0.67
HY-10006Flavopiridol Hydrochloride -
Similarity Score 0.67
HY-10005RFlavopiridol (Standard) -
Similarity Score 0.60
HY-153260TP-1287 -
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