1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. (2S,3R)-Voruciclib hydrochloride

(2S,3R)-Voruciclib hydrochloride 

Cat. No.: HY-12422B
Handling Instructions

(2S,3R)-Voruciclib hydrochloride is a potent CDK inhibitor with nM potency for CDKs 1, 4, 6, and 9 with strongest inhibition of CDK9. (2S,3R)-Voruciclib hydrochloride effectively induces apoptosis and has antitumor activity.

For research use only. We do not sell to patients.

(2S,3R)-Voruciclib hydrochloride Chemical Structure

(2S,3R)-Voruciclib hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 390 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (2S,3R)-Voruciclib hydrochloride:

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Description

(2S,3R)-Voruciclib hydrochloride is a potent CDK inhibitor with nM potency for CDKs 1, 4, 6, and 9 with strongest inhibition of CDK9. (2S,3R)-Voruciclib hydrochloride effectively induces apoptosis and has antitumor activity[1].

IC50 & Target

CDK1

 

CDK4

 

CDK6

 

CDK9

 

In Vitro

(2S,3R)-Voruciclib hydrochloride can shift cells to apoptosis when combined with Bcl-2 inhibition through inhibition of MCL-1 via CDK9[1].

In Vivo

(2S,3R)-Voruciclib hydrochloride (200 mg/kg) showes a marked reduction in normalized tumor volume in HCC1187 triple negative breast cancer (TNBC) xenograft mouse models[1].

Molecular Weight

506.30

Formula

C₂₂H₂₀Cl₂F₃NO₅

SMILES

Cl[H].ClC1=CC(C(F)(F)F)=CC=C1C(OC2=C(C(O)=CC(O)=C23)[[email protected]]([[email protected]]4CO)CCN4C)=CC3=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (493.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9751 mL 9.8756 mL 19.7511 mL
5 mM 0.3950 mL 1.9751 mL 3.9502 mL
10 mM 0.1975 mL 0.9876 mL 1.9751 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(2S,3R)-Voruciclib hydrochloride
Cat. No.:
HY-12422B
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