100079-26-3
100079-26-3
Chemical Structure
THPN
- CAS No.: 100079-26-3
- Formula:C15H22O4
- Molecular Weight:266.33
IUPAC Name: 1-(3,4,5-trihydroxyphenyl)nonan-1-one
InChIKey: NVFRHTFJDGAFQS-UHFFFAOYSA-N
SMILES: CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O
Biological Activity: THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].
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THPN | 98.00% | THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-1871441-(2,4,6-Trihydroxyphenyl)-1-octanone -
Similarity Score 0.72
HY-N10756Hyp9 -
Similarity Score 0.71
HY-145243PDPOB -
Similarity Score 0.71
HY-W7271442-Heptyl-4,6-dihydroxybenzoic acid -
Similarity Score 0.69
HY-124106Resorstatin -
Similarity Score 0.69
HY-14617Paradol -
Similarity Score 0.68
HY-N2148RCytosporone B (Standard) -
Similarity Score 0.67
HY-N131148-Gingerdione -
Similarity Score 0.67
HY-18405110-Fluoro-1-phenyldecan-1-one -
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References
- [1]. Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10(2):133-40. [Content Brief]
- [2]. Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11(5):339-46. [Content Brief]
