2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. THPN

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma.

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THPN Chemical Structure

THPN Chemical Structure

CAS No. : 100079-26-3

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THPN Related Antibodies

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Description

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

IC50 & Target

Nur77/NR4A1

 

Molecular Weight

266.33

Formula

C15H22O4
CAS No.
SMILES

CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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THPN Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THPN100079-26-3Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like Receptormelanoma cellNur77TR3Inhibitorinhibitorinhibit

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