2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. THPN

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma.

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THPN

THPN Chemical Structure

CAS No. : 100079-26-3

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Based on 1 publication(s) in Google Scholar

THPN Related Antibodies

Top Publications Citing Use of Products

View All Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products:

View All Isoforms
Nur77/NR4A1 Nurr1/NR4A2

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Description

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

IC50 & Target

Nur77/NR4A1

 

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
43 μM
Compound: 8
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 18295493]
CCRF-CEM IC50
50 μM
Compound: 8
Cytotoxicity against human CEM cells after 24 hrs by MTT assay
Cytotoxicity against human CEM cells after 24 hrs by MTT assay
[PMID: 18295493]
L1210 IC50
22 μM
Compound: 8
Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
[PMID: 18295493]
L1210 IC50
22 μM
Compound: 8
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 18295493]
Vero IC50
> 1 μM
Compound: 8
Cytotoxicity against african green monkey VERO cells
Cytotoxicity against african green monkey VERO cells
[PMID: 18295493]
Vero IC50
> 299 μM
Compound: 8
Genotoxicity against african green monkey VERO cells
Genotoxicity against african green monkey VERO cells
[PMID: 18295493]
Molecular Weight

266.33

Formula

C15H22O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.00%

SDS (392 KB)

COA (243 KB)

Handling Instructions (2659 KB)
References
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THPN Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THPN100079-26-3Nuclear Hormone Receptor 4A/NR4ANuclear Hormone Receptor 4ANerve Growth Factor IB-like Receptormelanoma cellNur77TR3Inhibitorinhibitorinhibit

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