1003311-62-3
1003311-62-3
Chemical Structure
c-Kit-IN-5-1
- CAS No.: 1003311-62-3
- Formula:C23H17N5O2
- Molecular Weight:395.41
IUPAC Name: 3-(2-aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one
InChIKey: IGFSMGCBFTXTJK-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC3=CN=C(N)N=C3C=C2)=C(C)C=CN1C4=CC=C(C5=NC=CO5)C=C4
Biological Activity: c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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c-Kit-IN-5-1 | 98.03% | c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.51
HY-13002Torin 2 -
Similarity Score 0.51
HY-145777AGI-43192 -
Similarity Score 0.51
HY-15281QL-IX-55 -
Similarity Score 0.50
HY-145778AGI-41998 -
Similarity Score 0.49
HY-124645QL-X-138 -
Similarity Score 0.48
HY-177286c-Kit-IN-11 -
Similarity Score 0.48
HY-142930MAT2A-IN-3 -
Similarity Score 0.48
HY-142929MAT2A-IN-2 -
Similarity Score 0.47
HY-183393NVP-BHS345 -
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