1053-73-2
1053-73-2
Chemical Structure
Adenosine-3',5'-bisphosphate
- No. CAS: 1053-73-2
- Formula:C10H15N5O10P2
- Molecular Weight:427.20
InChIKey: WHTCPDAXWFLDIH-KQYNXXCUSA-N
SMILES: O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2
Biological Activity: Adenosine-3',5'-bisphosphate is an exoribonuclease XRN1 inhibitor with an IC50 of 36 nM, a KD of 12 nM, and a KD of 14 nM against human XRN2. Adenosine-3',5'-bisphosphate binds to the bimetallic active site of human XRN1, and also binds potently to human XRN2 via its conserved bimetallic active site. Adenosine-3',5'-bisphosphate can be used in research related to non-small cell lung cancer[1].
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Adenosine-3',5'-bisphosphate | Adenosine-3',5'-bisphosphate is an exoribonuclease XRN1 inhibitor with an IC50 of 36 nM, a KD of 12 nM, and a KD of 14 nM against human XRN2. Adenosine-3',5'-bisphosphate binds to the bimetallic active site of human XRN1, and also binds potently to human XRN2 via its conserved bimetallic active site. Adenosine-3',5'-bisphosphate can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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