1068148-47-9
1068148-47-9
Chemical Structure
BIBP3226 TFA
- CAS No.: 1068148-47-9
- Formula:C29H32F3N5O5
- Molecular Weight:587.59
IUPAC Name: (R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide 2,2,2-trifluoroacetate
InChIKey: MTSZIDSCWZHKOD-GNAFDRTKSA-N
SMILES: FC(C(O)=O)(F)F.OC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O
Biological Activity: BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].
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BIBP3226 TFA | 99.92% | BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect. | ||||||||||||||||||||
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BIBP3226 TFA (Standard) | ≥98% | BIBP3226 TFA (Standard) is the analytical standard of BIBP3226 (TFA) (HY-107726). This product is intended for research and analytical applications. BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect. | ||||||||||||||||||||
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References
- [1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. [Content Brief]
- [2]. Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317(2-3):R3-4. [Content Brief]
Keywords
