110117-83-4
110117-83-4
Chemical Structure
Indoximod
Synonym(s): 1-Methyl-D-tryptophan; NLG-8189
- CAS No.: 110117-83-4
- Formula:C12H14N2O2
- Molecular Weight:218.26
IUPAC Name: 1-methyl-D-tryptophan
InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N
SMILES: N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O
Biological Activity: Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2].
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Indoximod | 99.54% | Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer. | ||||||||||||||||||||
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Indoximod (Standard) | ≥98% | Indoximod (Standard) is the analytical standard of Indoximod. This product is intended for research and analytical applications. Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Hou DY, et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophancorrelates with antitumor responses. Cancer Res. 2007 Jan 15;67(2):792-801. [Content Brief]
- [2]. Metz R, et al. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. Oncoimmunology. 2012;1(9):1460-1468. [Content Brief]
