1104546-89-5
1104546-89-5
Chemical Structure
BYK204165
- CAS No.: 1104546-89-5
- Formula:C15H12N2O2
- Molecular Weight:252.27
IUPAC Name: (Z)-4-((1-methyl-1H-pyrrol-2-yl)methylene)isoquinoline-1,3(2H,4H)-dione
InChIKey: BTYSIDSTHDDAJW-LCYFTJDESA-N
SMILES: O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O
Biological Activity: BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1].
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BYK204165 | 99.89% | BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1. | ||||||||||||||||||||
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BYK204165 (Standard) | ≥98% | BYK204165 (Standard) is the analytical standard of BYK204165 (HY-108632). This product is intended for research and analytical applications. BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1. | ||||||||||||||||||||
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References
Keywords
