111003-33-9
Chemical Structure
(-)-Taxifolin
Synonym(s): (-)-Dihydroquercetin
- CAS No.: 111003-33-9
- Formula:C15H12O7
- Molecular Weight:304.25
IUPAC Name: (2S,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
InChIKey: CXQWRCVTCMQVQX-CABCVRRESA-N
SMILES: O=C1[C@@H](O)[C@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
Biological Activity: (-)-Taxifolin is the low-activity isomer of Taxifolin. Taxifolin is an orally effective collagenase inhibitor with an IC50 of 193.3 μM. Taxifolin dose-dependently reduces the levels of Smad-2, α-SMA, CTGF, type I collagen, NF-κB and FN in renal tissues, while decreasing serum levels of IL-1β, TNF-α, MDA, Scr and BUN, increasing SOD levels and reversing 27 serum metabolic biomarkers. Taxifolin inhibits the growth of a variety of pathogenic bacteria. Taxifolin can be used in studies related to renal fibrosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(-)-Taxifolin | 98.98% | (-)-Taxifolin is the low-activity isomer of Taxifolin. Taxifolin is an orally effective collagenase inhibitor with an IC50 of 193.3 μM. Taxifolin dose-dependently reduces the levels of Smad-2, α-SMA, CTGF, type I collagen, NF-κB and FN in renal tissues, while decreasing serum levels of IL-1β, TNF-α, MDA, Scr and BUN, increasing SOD levels and reversing 27 serum metabolic biomarkers. Taxifolin inhibits the growth of a variety of pathogenic bacteria. Taxifolin can be used in studies related to renal fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Ren L, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Frontiers in pharmacology. 2020;11:608511. [Content Brief]
- [2]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules (Basel, Switzerland). 2016 Nov 21;21(11):1586. [Content Brief]
