1127308-52-4
1127308-52-4
Chemical Structure
ROCK inhibitor-2
- CAS No.: 1127308-52-4
- Formula:C21H20N2O2
- Molecular Weight:332.40
IUPAC Name: (R)-N-(1-(3-methoxyphenyl)ethyl)-4-(pyridin-4-yl)benzamide
InChIKey: JRVSFZKYQCETAH-OAHLLOKOSA-N
SMILES: O=C(N[C@H](C)C1=CC=CC(OC)=C1)C(C=C2)=CC=C2C3=CC=NC=C3
Biological Activity: ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ROCK inhibitor-2 | 99.92% | ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity. | ||||||||||||||||||||
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References
- [1]. Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100. [Content Brief]
- [2]. Zhang W, et al., 3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. J Nanobiotechnology. 2021 Sep 4;19(1):263. [Content Brief]
