118409-62-4
118409-62-4
Chemical Structure
AG126
Synonym(s): Tyrphostin AG126
- CAS No.: 118409-62-4
- Formula:C10H5N3O3
- Molecular Weight:215.17
IUPAC Name: 2-(3-hydroxy-4-nitrobenzylidene)malononitrile
InChIKey: DUQADSPERJRQBW-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C/C1=CC=C([N+]([O-])=O)C(O)=C1
Biological Activity: AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].
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AG126 | 98.0% | AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research. | ||||||||||||||||||||
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AG126 (Standard) | ≥98% | AG126 (Standard) is the analytical standard of AG126. This product is intended for research and analytical applications. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research. | ||||||||||||||||||||
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References
- [1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58. [Content Brief]
- [2]. Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5. [Content Brief]
- [3]. Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun;28(6):775-88. [Content Brief]
- [4]. Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1722-31. [Content Brief]
