1187451-41-7
1187451-41-7
Chemical Structure
Omidenepag
Synonym(s): UR-7276
- CAS No.: 1187451-41-7
- Formula:C23H22N6O4S
- Molecular Weight:478.52
IUPAC Name: (6-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)pyridin-2-yl)glycine
InChIKey: YHGSTSNEOJUIRN-UHFFFAOYSA-N
SMILES: O=C(O)CNC1=NC(CN(CC2=CC=C(N3N=CC=C3)C=C2)S(=O)(C4=CC=CN=C4)=O)=CC=C1
Biological Activity: Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Omidenepag | 99.86% | Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure. | ||||||||||||||||||||
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References
- [1]. Iwamura R, et al. Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. J Med Chem. 2018 Aug 9;61(15):6869-6891. [Content Brief]
- [2]. Nakamura N, et al. Effects of selective EP2 receptor agonist, omidenepag, on trabecular meshwork cells, Schlemm's canal endothelial cells and ciliary muscle contraction. Sci Rep. 2021 Aug 10;11(1):16257. [Content Brief]
