1223403-58-4
Chemical Structure
Larotrectinib
Synonym(s): LOXO-101; ARRY-470
- CAS No.: 1223403-58-4
- Formula:C21H22F2N6O2
- Molecular Weight:428.44
IUPAC Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
InChIKey: NYNZQNWKBKUAII-KBXCAEBGSA-N
SMILES: O=C(N1C[C@@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Biological Activity: Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Larotrectinib | 99.93% | Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Larotrectinib (Standard) | ≥98% | Larotrectinib (Standard) is the analytical standard of Larotrectinib. This product is intended for research and analytical applications. Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Larotrectinib-d4 | Larotrectinib-d4 (LOXO-101-d4) is the deuterium labeled Larotrectinib (HY-12866). Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 1.00
HY-12866B(R)-Larotrectinib -
Similarity Score 0.93
HY-12866ARLarotrectinib sulfate (Standard) -
Similarity Score 0.72
![(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate Chemical Structure](//file.medchemexpress.com/product_pic/hy-42697.gif)
HY-42697(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate -
Similarity Score 0.69
HY-153745Protein kinase inhibitor 5 -
Similarity Score 0.68
HY-152849Boditrectinib -
Similarity Score 0.67
HY-153743Protein kinase inhibitor 4 -
Similarity Score 0.65
HY-152849ABoditrectinib oxalate -
Similarity Score 0.63
HY-145587Paltimatrectinib -
Similarity Score 0.58
HY-152840Emzeltrectinib -
Explore the MedChemAI to find more analogs
![(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-42697.gif)
