1223405-08-0
Chemical Structure
Larotrectinib sulfate
Synonym(s): LOXO-101 sulfate; ARRY-470 sulfate
- CAS No.: 1223405-08-0
- Formula:C21H24F2N6O6S
- Molecular Weight:526.51
IUPAC Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
InChIKey: PXHANKVTFWSDSG-QLOBERJESA-N
SMILES: O=S(O)(O)=O.O=C(N1CC[C@H](O)C1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Biological Activity: Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Larotrectinib sulfate | 99.02% | Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). | ||||||||||||||||||||
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Larotrectinib sulfate (Standard) | ≥98% | Larotrectinib sulfate (Standard) is the analytical standard of Larotrectinib sulfate. This product is intended for research and analytical applications. Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). | ||||||||||||||||||||
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Similarity Score 0.93
HY-12866Larotrectinib -
Similarity Score 0.93
HY-12866B(R)-Larotrectinib -
Similarity Score 0.68
HY-153743Protein kinase inhibitor 4 -
Similarity Score 0.68
![(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate Chemical Structure](//file.medchemexpress.com/product_pic/hy-42697.gif)
HY-42697(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate -
Similarity Score 0.66
HY-153745Protein kinase inhibitor 5 -
Similarity Score 0.65
HY-152849ABoditrectinib oxalate -
Similarity Score 0.65
HY-152849Boditrectinib -
Similarity Score 0.60
HY-145587Paltimatrectinib -
Similarity Score 0.55
HY-152840Emzeltrectinib -
Explore the MedChemAI to find more analogs
![(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-42697.gif)
