1230-77-9
1230-77-9
Chemical Structure
DML3
- CAS No.: 1230-77-9
- Formula:C18H19NO2
- Molecular Weight:281.36
IUPAC Name: (E)-3-(4-(dimethylamino)phenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
InChIKey: VYCHTZRFUNDXSN-AWNIVKPZSA-N
SMILES: O=C(C=CC1=CC=C(C=C1)N(C)C)C2=CC=C(OC)C=C2
Biological Activity: DML3, a 5-methylcytosine DNA glycosylase, is a DNA demethylating agent. DML3 specifically recognizes and excises 5-methylcytosine (5-meC) from DNA through a base excision repair mechanism. DML3 is promising for research of plant epigenetic regulation and cancers[1][2].
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DML3 | DML3, a 5-methylcytosine DNA glycosylase, is a DNA demethylating agent. DML3 specifically recognizes and excises 5-methylcytosine (5-meC) from DNA through a base excision repair mechanism. DML3 is promising for research of plant epigenetic regulation and cancers. | |||||||||||||||||||||
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References
- [1]. Ortega-Galisteo AP, et al. Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks. Plant Mol Biol. 2008 Aug;67(6):671-81. [Content Brief]
- [2]. Len JM, et al. A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. Molecules. 2021 Jul 11;26(14):4214. [Content Brief]
Keywords
