1240797-41-4
Chemical Structure
Octreotide-d8
Synonym(s): SMS 201-995-d8
- CAS No.: 1240797-41-4
- Formula:C49H58D8N10O10S2
- Molecular Weight:1027.29
InChIKey: DEQANNDTNATYII-UXIPXJESSA-N
SMILES: O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(NC(CO)C(O)C)=O)NC(C(N)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)CC3=CC=CC=C3)N[C@H]1CC4=CNC5=CC=CC=C45
Biological Activity: Octreotide-d8 (SMS 201-995-d8) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].
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Octreotide-d8 | Octreotide-d8 (SMS 201-995-d8) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly. | |||||||||||||||||||||
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Octreotide-d8 acetate | Octreotide-d8 (acetate) (SMS 201-995-d8 (acetate)) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly. | |||||||||||||||||||||
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Octreotide-13C9，15N | Octreotide-13C9,15N (SMS 201-995-13C9,15N) is 13C and 15N labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly. | |||||||||||||||||||||
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Octreotide | 99.96% | Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly. | ||||||||||||||||||||
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Similarity Score 0.99
HY-P0036AOctreotide dihydrochloride -
Similarity Score 0.97
HY-17365Octreotide acetate -
Similarity Score 0.95
HY-P4980Acetyl-Lys5-octreotide -
Similarity Score 0.94
HY-P5085Acetyl-Octreotide -
Similarity Score 0.93
HY-P1622SDZ 204-090 -
Similarity Score 0.90
HY-P11463Des-threoninol-octreotide -
Similarity Score 0.88
HY-P10239Tyr3-Octreotate -
Similarity Score 0.87
HY-P3314Nendratareotide -
Similarity Score 0.86
HY-P4555(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Xiao-Xia Wang,et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16(1):109-118. [Content Brief]
