1245010-44-9
Chemical Structure
SPG-178
- CAS No.: 1245010-44-9
- Formula:C73H134N26O18
- Molecular Weight:1664.01
InChIKey: DWDGUBLFVWTCTK-UVTPLNMJSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: SPG-178 is a synthetic neutral Self-assembling peptide. In neutral aqueous solution, SPG-178 spontaneously assembles into an antiparallel β-sheet nanoscale three-dimensional hydrogel (SPG-178-Gel) through electrostatic and hydrophobic interactions, and biologically mimics the natural extracellular matrix (ECM) to provide a microenvironment that promotes cell proliferation and angiogenesis[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SPG-178 | SPG-178 is a synthetic neutral Self-assembling peptide. In neutral aqueous solution, SPG-178 spontaneously assembles into an antiparallel β-sheet nanoscale three-dimensional hydrogel (SPG-178-Gel) through electrostatic and hydrophobic interactions, and biologically mimics the natural extracellular matrix (ECM) to provide a microenvironment that promotes cell proliferation and angiogenesis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pal S, et al. Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application. ACS applied materials & interfaces. 2021 Apr 21;13(15):17300-17315.
- [2]. Wang B. The protective role of neurotrophin-4 in spinal cord injury. New Medicine. 2025 Jan;3(1):1-6.
- [3]. Yoshida W. Combined effects of systemic parathyroid hormone (1–34) and locally delivered neutral self‐assembling peptide hydrogel in the treatment of periodontal defects: An experimental in vivo investigation. Journal of clinical periodontology. 2019 Oct;46(10):1030-40.
- [4]. Rivas M, et al. Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite. Gels (Basel, Switzerland). 2019 Mar 06;5(1):14.
- [5]. Hua Y, et al. Applications of self-assembled peptide hydrogels in anti-tumor therapy. Nanoscale advances. 2024 Jun 11;6(12):2993-3008. [Content Brief]
- [6]. Mikamori M, et al. Self-assembling peptide hydrogel SPG-178 as a pancreatic fistula-preventing agent. Langenbeck's archives of surgery. 2022 Feb;407(1):189-196.
- [7]. Ando K, et al. Feasibility and effects of a self-assembling peptide as a scaffold in bone healing: An in vivo study in rabbit lumbar posterolateral fusion and tibial intramedullary models. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2018 Dec;36(12):3285-3293.
- [8]. Komatsu S, et al. The neutral self-assembling peptide hydrogel SPG-178 as a topical hemostatic agent. PloS one. 2014;9(7):e102778.
