1245653-57-9
1245653-57-9
Chemical Structure
HAMI 3379
- CAS No.: 1245653-57-9
- Formula:C34H45NO8
- Molecular Weight:595.72
IUPAC Name: 3-(((1S,3S)-3-carboxycyclohexyl)carbamoyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid
InChIKey: HRJWSEPIRZRGCL-BDYUSTAISA-N
SMILES: O=C(O)C1=CC=C(OCCCC2=CC=C(OCCCCOC3CCCCC3)C=C2)C(C(N[C@@H]4C[C@@H](C(O)=O)CCC4)=O)=C1
Biological Activity: HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HAMI 3379 | 98.64% | HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-112248(Rac)-HAMI 3379 -
Similarity Score 0.82
HY-116326BayCysLT2 -
Similarity Score 0.50
HY-112740SC-53228 -
Similarity Score 0.49
HY-183340Antibacterial agent 341 -
Similarity Score 0.47
HY-123394AP-22161 -
Similarity Score 0.47
HY-112737LY223982 -
Similarity Score 0.47
HY-124100LTB4 antagonist 4 -
Similarity Score 0.47
HY-118958Ablukast -
Similarity Score 0.46
HY-20019RL-165041 (Standard) -
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References
- [1]. F Wunder, et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010 May;160(2):399-409. [Content Brief]
- [2]. Q J Shi, et al. HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats. Neuroscience. 2015 Apr 16;291:53-69. [Content Brief]
