2. GPCR/G Protein
  3. Leukotriene Receptor
  4. HAMI 3379

HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation.

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HAMI 3379 Chemical Structure

HAMI 3379 Chemical Structure

CAS No. : 1245653-57-9

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Based on 1 publication(s) in Google Scholar

Other Forms of HAMI 3379:

HAMI 3379 Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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  • Customer Review

Description

HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation[1][2].

IC50 & Target[1]

CysLT2

 

In Vitro

In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes leukotriene D4- (LTD4-) and leukotriene C4- (LTC4-) induced intracellular calcium mobilization with IC50 values of 3.8 nM and 4.4 nM respectively. HAMI3379 exhibits very low potency on a recombinant CysLT1 receptor cell line (IC50>10000 nM). HAMI3379 does not exhibit any agonistic activity on both CysLT receptor cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HAMI 3379 Related Antibodies
In Vivo

HAMI 3379 (0.025-0.4 mg/kg; ip) with 0.1-0.4 mg/kg significantly reduces the infarct volume and percentage increase in the ischemic/contralateral hemispheric ratio[2].
HAMI3379 (0.1 mg/kg; ip) administered at 0 and 1 h after reperfusion reduces infarct volume, attenuated brain edema, reduced neurological score, and increased holdingangle[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) after MCAO[2]
Dosage: 0.025, 0.05, 0.1, 0.2, 0.4 mg/kg
Administration: IP
Result: Significantly reduced the infarct volume and percentage increase inthe ischemic/contralateral hemispheric ratio (an index ofbrain edema) with 0.1-0.4 mg/kg.
Significantly reduced the neurological deficit score.
Molecular Weight

595.72

Formula

C34H45NO8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(OCCCC2=CC=C(OCCCCOC3CCCCC3)C=C2)C(C(N[C@@H]4C[C@@H](C(O)=O)CCC4)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (167.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6786 mL 8.3932 mL 16.7864 mL
5 mM 0.3357 mL 1.6786 mL 3.3573 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.76%

COA (245 KB) HNMR (344 KB) RP-HPLC (260 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6786 mL 8.3932 mL 16.7864 mL 41.9660 mL
5 mM 0.3357 mL 1.6786 mL 3.3573 mL 8.3932 mL
10 mM 0.1679 mL 0.8393 mL 1.6786 mL 4.1966 mL
15 mM 0.1119 mL 0.5595 mL 1.1191 mL 2.7977 mL
20 mM 0.0839 mL 0.4197 mL 0.8393 mL 2.0983 mL
25 mM 0.0671 mL 0.3357 mL 0.6715 mL 1.6786 mL
30 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3989 mL
40 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL
50 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
60 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
80 mM 0.0210 mL 0.1049 mL 0.2098 mL 0.5246 mL
100 mM 0.0168 mL 0.0839 mL 0.1679 mL 0.4197 mL
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HAMI 3379 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HAMI 33791245653-57-9HAMI3379HAMI-3379Leukotriene ReceptorCysteinylleukotrieneCysLT2CysLTprotectivebraininjurymicroglia-relatedinflammationInhibitorinhibitorinhibit

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