1. GPCR/G Protein
  2. Leukotriene Receptor
  3. HAMI 3379

HAMI 3379 

Cat. No.: HY-112248A
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HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation.

For research use only. We do not sell to patients.

HAMI 3379 Chemical Structure

HAMI 3379 Chemical Structure

CAS No. : 1245653-57-9

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Description

HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation[1][2].

IC50 & Target[1]

CysLT2

 

In Vitro

In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes leukotriene D4- (LTD4-) and leukotriene C4- (LTC4-) induced intracellular calcium mobilization with IC50 values of 3.8 nM and 4.4 nM respectively. HAMI3379 exhibits very low potency on a recombinant CysLT1 receptor cell line (IC50>10000 nM). HAMI3379 does not exhibit any agonistic activity on both CysLT receptor cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HAMI 3379 (0.025-0.4 mg/kg; ip) with 0.1-0.4 mg/kg significantly reduces the infarct volume and percentage increase in the ischemic/contralateral hemispheric ratio[2].
HAMI3379 (0.1 mg/kg; ip) administered at 0 and 1 h after reperfusion reduces infarct volume, attenuated brain edema, reduced neurological score, and increased holdingangle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) after MCAO[2]
Dosage: 0.025, 0.05, 0.1, 0.2, 0.4 mg/kg
Administration: IP
Result: Significantly reduced the infarct volume and percentage increase inthe ischemic/contralateral hemispheric ratio (an index ofbrain edema) with 0.1-0.4 mg/kg.
Significantly reduced the neurological deficit score.
Molecular Weight

595.72

Formula

C₃₄H₄₅NO₈

CAS No.
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Product Name:
HAMI 3379
Cat. No.:
HY-112248A
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