1246525-60-9
1246525-60-9
Chemical Structure
SR1078
- CAS No.: 1246525-60-9
- Formula:C17H10F9NO2
- Molecular Weight:431.25
IUPAC Name: N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide
InChIKey: DUXWIYXHHGNUJU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C1)C2=CC=C(C(F)(F)F)C=C2
Biological Activity: SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR1078 | 99.75% | SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.73
HY-101454SR0987 -
Similarity Score 0.67
HY-134753Teriflunomide impurity 3 -
Similarity Score 0.63
HY-179514Gala-SR -
Similarity Score 0.61
HY-W0805632,2-Bis(4-carboxyphenyl)hexafluoropropane -
Similarity Score 0.59
HY-138831AES-350 -
Similarity Score 0.57
HY-112731TFAP -
Similarity Score 0.56
HY-120785SR1555 -
Similarity Score 0.56
HY-W654078Bisphenol AF-13C12 -
Similarity Score 0.56
HY-W5869834-(4-Carboxybenzamido)benzoic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Wang Y, et al. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol. 2010 Nov 19;5(11):1029-34. [Content Brief]
- [2]. Wang Y, Billon C, Walker JK, Burris TP. Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci. 2016;7(2):143-148. [Content Brief]
