1333151-73-7
1333151-73-7
Chemical Structure
KPT-185
- CAS No.: 1333151-73-7
- Formula:C16H16F3N3O3
- Molecular Weight:355.31
IUPAC Name: isopropyl (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
InChIKey: NLNGWFLRRRYNIL-PLNGDYQASA-N
SMILES: O=C(OC(C)C)/C=C\N1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1
Biological Activity: KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KPT-185 | 99.04% | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.59
HY-17539KPT-276 -
Similarity Score 0.55
HY-15970Verdinexor -
Similarity Score 0.55
HY-17536A(E)-Selinexor -
Similarity Score 0.55
HY-17536RSelinexor (Standard) -
Similarity Score 0.54
HY-117996KPT-251 -
Similarity Score 0.51
HY-100423Eltanexor -
Similarity Score 0.51
HY-100423AEltanexor Z-isomer -
Similarity Score 0.48
HY-144763XPO1-IN-1 -
Similarity Score 0.48
HY-172232STG-001 -
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