1333151-73-7
1333151-73-7
Chemical Structure
KPT-185
- CAS No.: 1333151-73-7
- Formula:C16H16F3N3O3
- Molecular Weight:355.31
IUPAC Name: isopropyl (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
InChIKey: NLNGWFLRRRYNIL-PLNGDYQASA-N
SMILES: O=C(OC(C)C)/C=C\N1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1
Biological Activity: KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
KPT-185 | 99.04% | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
