1345964-89-7
Chemical Structure
ML154
Synonym(s): NCGC84
- CAS No.: 1345964-89-7
- Formula:C29H26BrN2PS
- Molecular Weight:545.47
IUPAC Name: 1-cinnamyl-3-(diphenylphosphorothioyl)-2-methylimidazo[1,2-a]pyridin-1-ium bromide
InChIKey: CJAQCMBWGUOBIX-ZUQRMPMESA-M
SMILES: S=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=C(C)[N+](C/C=C/C4=CC=CC=C4)=C5N3C=CC=C5.[Br-]
Biological Activity: ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML154 | 99.59% | ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. | ||||||||||||||||||||
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- [1]. Annika Thorsell, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013 Jun 12;33(24):10132-42. [Content Brief]
- [2]. İrem Akçalı, et al. The regulatory role of central neuropeptide-S in locomotion. Peptides. 2023 Dec:170:171110. [Content Brief]
Keywords
