134615-37-5
Chemical Structure
Reveromycin A
- CAS No.: 134615-37-5
- Formula:C36H52O11
- Molecular Weight:660.79
IUPAC Name: (2E,4S,5S,6E,8E)-10-((2R,3S,6S,8S,9R)-9-butyl-8-((1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl)-9-((3-carboxypropanoyl)oxy)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
InChIKey: ZESGNAJSBDILTB-OXVOKJAASA-N
SMILES: O=C(O[C@@]1(CCCC)[C@H](/C=C/C(C)=C/C(O)=O)O[C@]2(O[C@H](C/C=C(C)/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)[C@@H](C)CC2)CC1)CCC(O)=O
Biological Activity: Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2].
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Reveromycin A | Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity. | |||||||||||||||||||||
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References
- [1]. H Takahashi , et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J Antibiot (Tokyo). 1992 Sep;45(9):1414-9. [Content Brief]
- [2]. Je-Tae Woo, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34. [Content Brief]
