135248-05-4
Chemical Structure
Moracin N
- CAS No.: 135248-05-4
- Formula:C19H18O4
- Molecular Weight:310.34
InChIKey: WBSCSIABHGPAMC-UHFFFAOYSA-N
SMILES: OC1=CC(C2=CC3=C(C=C(C(C/C=C(C)\C)=C3)O)O2)=CC(O)=C1
Biological Activity: Moracin N is a benzofuran compound. At low concentrations, Moracin N activates the Keap1/Nrf2 pathway, downregulates the expression of FTH1 and ACSL4, enhances glutathione synthesis, and inhibits neuronal ferroptosis. At high concentrations, Moracin N induces ROS accumulation, activates mitochondrial apoptosis, and triggers autophagy-mediated cell death by inhibiting the AKT/mTOR pathway. Moracin N can be used in research related to non-small cell lung cancer, hepatocellular carcinoma and ischemic brain injury[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Moracin N | 98.02% | Moracin N is a benzofuran compound. At low concentrations, Moracin N activates the Keap1/Nrf2 pathway, downregulates the expression of FTH1 and ACSL4, enhances glutathione synthesis, and inhibits neuronal ferroptosis. At high concentrations, Moracin N induces ROS accumulation, activates mitochondrial apoptosis, and triggers autophagy-mediated cell death by inhibiting the AKT/mTOR pathway. Moracin N can be used in research related to non-small cell lung cancer, hepatocellular carcinoma and ischemic brain injury. | ||||||||||||||||||||
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- [1]. Gao C, et al. A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer. Frontiers in pharmacology. 2020;11:391. [Content Brief]
- [2]. Zhang J, et al. Moracin N alleviates ischaemic brain injury in mice by suppressing neuronal ferroptosis via the activation of the Keap1/Nrf2 signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2025 Nov 25;148:157253. [Content Brief]
- [3]. Tu J, et al. Identification of moracin N in mulberry leaf and evaluation of antioxidant activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Oct;132:110730. [Content Brief]
Keywords
